Helminth egg derivatives as proregenerative immunotherapies
Abstract
The immune system is increasingly recognized as an important regulator of tissue repair. We developed a regenerative immunotherapy from the helminth Schistosoma mansoni soluble egg antigen (SEA) to stimulate production of interleukin (IL)-4 and other type 2-associated cytokines without negative infection-related sequelae. The regenerative SEA (rSEA) applied to a murine muscle injury induced accumulation of IL-4-expressing T helper cells, eosinophils, and regulatory T cells and decreased expression of IL-17A in gamma delta (γδ) T cells, resulting in improved repair and decreased fibrosis. Encapsulation and controlled release of rSEA in a hydrogel further enhanced type 2 immunity and larger volumes of tissue repair. The broad regenerative capacity of rSEA was validated in articular joint and corneal injury models. These results introduce a regenerative immunotherapy approach using natural helminth derivatives.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 13, 2023
- Source ID
- 10.1073/pnas.2211703120
Entities
People
- Alexander F. Chin
- Alexis N. Peña
- Amy E. Anderson
- Christopher Mejia
- Cynthia A. Berlinicke
- David R Maestas
- Don Zack
- Drew M Pardoll
- Edward J. Pearce
- Erika Moore
- Franck Housseau
- Helen Hieu Nguyen
- Hong Zhang
- J. Woo
- James I Andorko
- Jennifer Elisseeff
- Jin Han
- Joscelyn C. Mejías
- Joshua S. T. Hooks
- Kavita Krishnan
- Liam Chung
- Liang Zhao
- Marie Eric
- Ronak J. Mahatme
- Sean H Kelly
- Sudipto Ganguly
- Sven D. Sommerfeld
- Xiaokun Wang
- Younghwan Choi
Organizations
- Bloomberg L.P.
- Johns Hopkins University
- National Eye Institute
- National Institutes of Health
- United States Department of Defense
- University of Florida