Towards mechanisms and standardization in extracellular vesicle and extracellular RNA studies: results of a worldwide survey
Abstract
The discovery that extracellular vesicles (EVs) can transfer functional extracellular RNAs (exRNAs) between cells opened new avenues into the study of EVs in health and disease. Growing interest in EV RNAs and other forms of exRNA has given rise to research programmes including but not limited to the Extracellular RNA Communication Consortium (ERCC) of the US National Institutes of Health. In 2017, the International Society for Extracellular Vesicles (ISEV) administered a survey focusing on EVs and exRNA to canvass‐related views and perceived needs of the EV research community. Here, we report the results of this survey. Overall, respondents emphasized opportunities for technical developments, unraveling of molecular mechanisms and standardization of methodologies to increase understanding of the important roles of exRNAs in the broader context of EV science. In conclusion, although exRNA biology is a relatively recent emphasis in the EV field, it has driven considerable interest and resource commitment. The ISEV community looks forward to continuing developments in the science of exRNA and EVs, but without excluding other important molecular constituents of EVs.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 24, 2018
- Source ID
- 10.1080/20013078.2018.1535745
Entities
People
- Andrew F. Hill
- Carolina Soekmadji
- Chris Gardiner
- Dolores Di Vizio
- Edit I. Buzás
- Jan Lötvall
- Kenneth W. Witwer
- Marca H. Wauben
- Susmita Sahoo
Organizations
- Cedars-Sinai Medical Center
- Icahn School of Medicine at Mount Sinai
- Johns Hopkins University
- La Trobe University
- National Institute on Drug Abuse
- QIMR Berghofer Medical Research Institute
- Semmelweis University
- United States Department of Defense
- University College London
- University of Gothenburg
- Utrecht University