Nuclear envelope rupture: Actin fibers are putting the squeeze on the nucleus
Abstract
Cells exhibit transient nuclear envelope ruptures during interphase, but the responsible biophysical processes remain unclear. In this issue, Hatch and Hetzer (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603053) show that actin fibers constrict the nucleus, causing chromatin protrusions and nuclear membrane ruptures at sites with nuclear lamina defects.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 03, 2016
- Source ID
- 10.1083/jcb.201609102
Entities
People
- Jan Lammerding
- Katarina Wolf
Organizations
- Cornell University
- Dutch Research Council
- National Institutes of Health
- National Science Foundation
- Radboud University Medical Centre
- Radboud University Nijmegen
- United States Department of Defense