ORP5 regulates PI(4)P on the lipid droplet: Novel players on the monolayer
Abstract
How the distinct lipid composition of organelles is determined and maintained is still poorly understood. In this issue, Du et al. (2019. J. Cell Biol.https://doi.org/10.1083/jcb.201905162) show that the lipid transfer protein ORP5 functions at ER–LD contact sites, regulating lipid droplet levels of phosphatidylserine and phosphatidylinositol-4-phosphate.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 23, 2019
- Source ID
- 10.1083/jcb.201912010
Entities
People
- Brooke M Emerling
- Mike F Renne
Organizations
- Sanford Burnham Prebys Medical Discovery Institute
- United States Department of Defense
- University of Oxford