Think globally, act locally: Centrosome-localized mRNAs ensure mitotic fidelity
Abstract
The functional importance of mRNA localization to centrosomes is unclear. Ryder et al. (2020. J. Cell Biol. https://doi.org/10.1083/jcb.202004101) identify fragile-X mental retardation protein as a regulator of centrocortin (cen) mRNA dynamics in Drosophila. Mistargeting of cen impairs division and development, indicating that cen mRNA localization to centrosomes ensures mitotic fidelity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 20, 2020
- Source ID
- 10.1083/jcb.202010172
Entities
People
- Daniela C Zarnescu
Organizations
- National Institutes of Health
- United States Department of Defense
- University of Arizona