When aging gets on the way of disposal: Senescent cell suppression of efferocytosis
Abstract
Chronic senescence can trigger pathological inflammation. In this issue, Schloesser et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202207097) demonstrate that senescent cells employ “don’t eat me” signals that inhibit the ability of macrophages to engulf them and additionally prevent macrophages from removing neighboring corpses, revealing a new mechanism by which senescence may contribute to triggering inflammation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 05, 2023
- Source ID
- 10.1083/jcb.202212023
Entities
People
- Carla V. Rothlin
- Sourav Ghosh
Organizations
- Kenneth Rainin Foundation
- National Institutes of Health
- United States Department of Defense
- Yale School of Medicine