BRAG about (s)lots

Abstract

Mutations in IQSEC2/BRAG1 cause intellectual dysfunction by impairing ARF-GEF activity and long-term depression. In this issue, Bai et al. (https://doi.org/10.1083/jcb.202307117) discover how constitutive ARF-GEF activity is regulated by a closed conformation which opens in the presence of Ca2+. Two known pathogenic mutations cause “leaky” autoinhibition with reduced synaptic dynamic range and impaired cognitive performance.

Document Details

• Document Type: Pub Defense Publication
• Publication Date: Nov 08, 2023
• Source ID: 10.1083/jcb.202310023

Entities

People

• Johannes W Hell
• Joshua C Brown
• Nashaat Z. Gerges

Organizations

• Brain & Behavior Research Foundation
• Harvard Medical School
• McLean Hospital
• Medical College of Wisconsin
• National Institutes of Health
• UC Davis Medical Center
• United States Department of Defense

Tags

Readers

• Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
• Molecular and Cellular Biochemistry
• Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.