Toward a better understanding of folate metabolism in health and disease
Abstract
Folate metabolism is crucial for many biochemical processes, including purine and thymidine monophosphate (dTMP) biosynthesis, mitochondrial protein translation, and methionine regeneration. These biochemical processes in turn support critical cellular functions such as cell proliferation, mitochondrial respiration, and epigenetic regulation. Not surprisingly, abnormal folate metabolism has been causally linked with a myriad of diseases. In this review, we provide a historical perspective, delve into folate chemistry that is often overlooked, and point out various missing links and underdeveloped areas in folate metabolism for future exploration.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 26, 2018
- Source ID
- 10.1084/jem.20181965
Entities
People
- Lewis C. Cantley
- Yuxiang Zheng
Organizations
- California Breast Cancer Research Program
- Lustgarten Foundation for Pancreatic Cancer Research
- National Cancer Institute
- United States Department of Defense