Iron overload and liver cancer
Abstract
In this issue of JEM, Muto et al. (https://doi.org/10.1084/jem.20180900) generate a novel mouse model of liver cancer induced by iron overload by deleting the iron-sensing ubiquitin ligase FBXL5 specifically in hepatocytes and exposure to a chemical carcinogen.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 18, 2019
- Source ID
- 10.1084/jem.20190257
Entities
People
- Amaia Lujambio
- Pedro Molina-sánchez
Organizations
- Damon Runyon Cancer Research Foundation
- Icahn School of Medicine at Mount Sinai
- National Cancer Institute
- National Institutes of Health
- Pfizer
- United States Department of Defense