Neutrophil phenotypes and functions in cancer: A consensus statement
Abstract
Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 06, 2022
- Source ID
- 10.1084/jem.20220011
Entities
People
- Andrea Rubio-Ponce
- Andrés Hidalgo
- Anna Huttenlocher
- Arturo Zychlinsky
- Betsy J Barnes
- Borko Amulic
- Daniela F Quail
- Denisa D Wagner
- Etienne Meylan
- Evgeniy B Eruslanov
- Helen S. Goodridge
- Ilaria Malanchi
- Irina Udalova
- Karina Elizabeth de Visser
- Mariana J. Kaplan
- Mikael Pittet
- Mikala Egeblad
- Monowar Aziz
- Paul Kubes
- Ping Wang
- Taha Merghoub
- Timo K van den Berg
- Vivek Mittal
- Zvi Fridlender
- Zvi Granot
Organizations
- Canada Research Chair
- Canadian Institutes of Health Research
- Cancer Research UK
- Cold Spring Harbor Laboratory
- Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
- European Commission
- European Research Council
- Francis Crick Institute
- Geneva University Hospitals
- German Research Foundation
- Harvard Medical School
- Hebrew University of Jerusalem
- Israel Cancer Research Fund
- Israel Science Foundation
- KWF Kankerbestrijding
- Leiden University Medical Center
- Ludwig Institute for Cancer Research
- Max Planck Institute for Infection Biology
- Max Planck Society
- McGill University
- Medical Research Council
- Memorial Sloan Kettering Cancer Center
- Ministry of Science of Spain
- National Cancer Institute
- National Center for Cardiovascular Research
- National Fund for Scientific Research
- National Heart, Lung, and Blood Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Institute of General Medical Sciences
- National Institutes of Health
- Oncode Institute
- Parker Institute for Cancer Immunotherapy
- Rosetrees Trust
- Sanquin Research
- Swim Across America
- Swiss National Science Foundation
- The Feinstein Institute for Medical Research
- United States Department of Defense
- University of Bristol
- University of Calgary
- University of Geneva
- University of Oxford
- University of Pennsylvania
- University of Wisconsin–Madison
- Université Libre de Bruxelles
- Weill Cornell Medicine
- Wellcome
- Yale University