The enduring legacy of the “constant-field equation” in membrane ion transport
Abstract
In 1943, David Goldman published a seminal paper in The Journal of General Physiology that reported a concise expression for the membrane current as a function of ion concentrations and voltage. This body of work was, and still is, the theoretical pillar used to interpret the relationship between a cell’s membrane potential and its external and/or internal ionic composition. Here, we describe from an historical perspective the theory underlying the constant-field equation and its application to membrane ion transport.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 20, 2017
- Source ID
- 10.1085/jgp.201711839
Entities
People
- Osvaldo Alvarez
- Ramon Latorre
Organizations
- Air Force Office of Scientific Research
- National Fund for Scientific and Technological Development
- University of Granada Faculty of Sciences
- University of Valparaíso