Phase-sensitive detection of anomalous diffusion dynamics in the neuronal membrane induced by ion channel gating
Abstract
Non-ergodicity of neuronal dynamics from rapid ion channel gating through the membrane induces membrane displacement statistics that deviate from Brownian motion. The membrane dynamics from ion channel gating were imaged by phase-sensitive optical coherence microscopy. The distribution of optical displacements of the neuronal membrane showed a Lévy-like distribution and the memory effect of the membrane dynamics by the ionic gating was estimated. The alternation of the correlation time was observed when neurons were exposed to channel-blocking molecules. Non-invasive optophysiology by detecting the anomalous diffusion characteristics of dynamic images is demonstrated.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 13, 2023
- Source ID
- 10.1088/1361-6560/acbf9c
Entities
People
- Carlos Renteria
- Honggu Choi
- Rishyashring R Iyer
- Stephen A. Boppart
Organizations
- Air Force Office of Scientific Research
- National Institutes of Health