Sources of off-target effects of vagus nerve stimulation using the helical clinical lead in domestic pigs
Abstract
Clinical data suggest that efficacious vagus nerve stimulation (VNS) is limited by side effects such as cough and dyspnea that have stimulation thresholds lower than those for therapeutic outcomes. VNS side effects are putatively caused by activation of nearby muscles within the neck, via direct muscle activation or activation of nerve fibers innervating those muscles. Our goal was to determine the thresholds at which various VNS-evoked effects occur in the domestic pig—an animal model with vagus anatomy similar to human—using the bipolar helical lead deployed clinically.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 23, 2020
- Source ID
- 10.1088/1741-2552/ab9db8
Entities
People
- Andrea L. Mcconico
- Andrew J. Shoffstall
- Brian A. Gosink
- Bruce E. Knudsen
- Erika K. Ross
- Evan N Nicolai
- Ian W. Baumgart
- James K Trevathan
- Justin C Williams
- Kenneth J Gustafson
- Kip Ludwig
- Megan L Settell
- Nicole Pelot
- Warren M Grill
Organizations
- Defense Advanced Research Projects Agency
- Division of Program Coordination Planning and Strategic Initiatives
- National Center for Advancing Translational Sciences