Nonmuscle myosin IIB is a driver of cellular reprogramming
Abstract
To test the impact of engineering cells with altered contractile properties, NMIIB and mutants that have different assembly and force-generating properties were introduced. Adding NMIIB into pancreatic ductal epithelia–derived cancer cells led to altered cell morphology. Additionally, NMIIB is highly integrated with a range of cellular systems, including metabolism and gene expression. Modifying the contractile machinery leads to cellular reprogramming.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 01, 2023
- Source ID
- 10.1091/mbc.e21-08-0386
Entities
People
- Amanda E. Balaban
- Douglas N. Robinson
- Eleana Parajón
- Ly T. S. Nguyen
Organizations
- Johns Hopkins University