Ivabradine-Induced Bradycardia is Accompanied by Reduced Stress-Related Anxiety
Abstract
Hypertensive individuals with higher heart rates and anxiety have greater cardiovascular morbidity and mortality. Despite the correlation between hypertension, heart rate, and anxiety, scant attention has been paid to the effect of hypertension drug therapy on behavioral outcomes in cardiovascular disease. Ivabradine, an inhibitor of hyperpolarization-activated, cyclic nucleotide-gated funny channels (HCNs), has been used clinically to reduce heart rates and has been shown to improve quality of life in patients with angina and heart failure. We postulated that in addition to lowering heart rate, ivabradine could reduce anxiety in mice exposed to a significant stress paradigm.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 22, 2023
- Source ID
- 10.1093/ajh/hpad019
Entities
People
- Coleman Miller
- Jeffrey Student
- Ryan Woodman
- Warren Lockette
Organizations
- Congressionally Directed Medical Research Programs
- Drexel University
- United States Department of Defense
- University of California
- University of Missouri
- Wayne State University