Identification of evolutionarily stable functional and immunogenic sites across the SARS-CoV-2 proteome and greater coronavirus family
Abstract
Since the first recognized case of COVID-19, more than 100 million people have been infected worldwide. Global efforts in drug and vaccine development to fight the disease have yielded vaccines and drug candidates to cure COVID-19. However, the spread of SARS-CoV-2 variants threatens the continued efficacy of these treatments. In order to address this, we interrogate the evolutionary history of the entire SARS-CoV-2 proteome to identify evolutionarily conserved functional sites that can inform the search for treatments with broader coverage across the coronavirus family.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 27, 2021
- Source ID
- 10.1093/bioinformatics/btab406
Entities
People
- Amanda M Williams
- Brigitta Wastuwidyaningtyas
- Chen Wang
- Daniel M Konecki
- David C Marciano
- Harikumar Govindarajan
- Olivier Lichtarge
- Panagiotis Katsonis
- Thomas Bourquard
Organizations
- Baylor College of Medicine
- Intelligence Advanced Research Projects Activity
- National Institutes of Health
- National Science Foundation
- Office of the Director of National Intelligence