scKINETICS: inference of regulatory velocity with single-cell transcriptomics data
Abstract
Transcriptional dynamics are governed by the action of regulatory proteins and are fundamental to systems ranging from normal development to disease. RNA velocity methods for tracking phenotypic dynamics ignore information on the regulatory drivers of gene expression variability through time.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 01, 2023
- Source ID
- 10.1093/bioinformatics/btad267
Entities
People
- Cassandra Burdziak
- Chujun Julia Zhao
- Dana Pe'er
- Direna Alonso-curbelo
- Doron Haviv
- Scott W. Lowe
Organizations
- Barcelona Institute for Science and Technology
- Columbia University
- Howard Hughes Medical Institute
- Memorial Sloan Kettering Cancer Center
- Ministry of Science of Spain
- National Cancer Institute
- United States Department of Defense