GRIMM: GRaph IMputation and matching for HLA genotypes
Abstract
For over 10 years allele-level HLA matching for bone marrow registries has been performed in a probabilistic context. HLA typing technologies provide ambiguous results in that they could not distinguish among all known HLA alleles equences; therefore registries have implemented matching algorithms that provide lists of donor and cord blood units ordered in terms of the likelihood of allele-level matching at specific HLA loci. With the growth of registry sizes, current match algorithm implementations are unable to provide match results in real time.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 28, 2019
- Source ID
- 10.1093/bioinformatics/btz050
Entities
People
- Jason Brelsford
- Joel P. Schneider
- Loren Gragert
- Martin Maiers
- Michael Halagan
- Polina Lutsker
- Pradeep Bashyal
- Yoram Louzoun
Organizations
- Bar-Ilan University
- Office of Naval Research
- Tulane University of Louisiana