Predicting the optimal growth temperatures of prokaryotes using only genome derived features
Abstract
Optimal growth temperature is a fundamental characteristic of all living organisms. Knowledge of this temperature is central to the study of a prokaryote, the thermal stability and temperature dependent activity of its genes, and the bioprospecting of its genome for thermally adapted proteins. While high throughput sequencing methods have dramatically increased the availability of genomic information, the growth temperatures of the source organisms are often unknown. This limits the study and technological application of these species and their genomes. Here, we present a novel method for the prediction of growth temperatures of prokaryotes using only genomic sequences.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 25, 2019
- Source ID
- 10.1093/bioinformatics/btz059
Entities
People
- Da-Neng Wang
- David Bryant Sauer
Organizations
- American Cancer Society
- Grossman School of Medicine
- National Institutes of Health
- United States Department of Defense