arcasHLA: high-resolution HLA typing from RNAseq
Abstract
The human leukocyte antigen (HLA) locus plays a critical role in tissue compatibility and regulates the host response to many diseases, including cancers and autoimmune di3orders. Recent improvements in the quality and accessibility of next-generation sequencing have made HLA typing from standard short-read data practical. However, this task remains challenging given the high level of polymorphism and homology between HLA genes. HLA typing from RNA sequencing is further complicated by post-transcriptional modifications and bias due to amplification.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 07, 2019
- Source ID
- 10.1093/bioinformatics/btz474
Entities
People
- Devon Comito
- Ioan Filip
- Itsik Pe’er
- Jeffrey Shaman
- Raúl Rabadán
- Rose Orenbuch
Organizations
- Columbia University
- Defense Advanced Research Projects Agency
- National Institutes of Health