Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of port-wine birthmark
Abstract
Lesional induced pluripotent stem cell-derived endothelial cells can resemble pathological vascular phenotypes of port-wine birthmark (PWB). Our data demonstrate that multiple pathways, including Hippo and Wnt, NFκB, TNF, MAPK and cholesterol metabolism, are dysregulated. These data suggest new therapeutics can be developed to target such dysregulated pathways in the treatment of PWB.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 06, 2023
- Source ID
- 10.1093/bjd/ljad330
Entities
People
- Anil G. Jegga
- Camilla F Wenceslau
- Chao Gao
- Dong-Bao Chen
- Elliott H Chen
- Harold I. Friedman
- J. Stuart Nelson
- Jacob Kravitz
- Marcelo L. Hochman
- Vi Nguyen
- Wenbin Tan
- Yunguan Wang
Organizations
- Cincinnati Children's Hospital Medical Center
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Institutes of Health
- United States Department of Defense
- University of Cincinnati
- University of South Carolina