Hippocampus co-atrophy pattern in dementia deviates from covariance patterns across the lifespan
Abstract
The hippocampus is a plastic region and highly susceptible to ageing and dementia. Previous studies explicitly imposed a priori models of hippocampus when investigating ageing and dementia-specific atrophy but led to inconsistent results. Consequently, the basic question of whether macrostructural changes follow a cytoarchitectonic or functional organization across the adult lifespan and in age-related neurodegenerative disease remained open. The aim of this cross-sectional study was to identify the spatial pattern of hippocampus differentiation based on structural covariance with a data-driven approach across structural MRI data of large cohorts (n = 2594). We examined the pattern of structural covariance of hippocampus voxels in young, middle-aged, elderly, mild cognitive impairment and dementia disease samples by applying a clustering algorithm revealing differentiation in structural covariance within the hippocampus. In all the healthy and in the mild cognitive impaired participants, the hippocampus was robustly divided into anterior, lateral and medial subregions reminiscent of cytoarchitectonic division. In contrast, in dementia patients, the pattern of subdivision was closer to known functional differentiation into an anterior, body and tail subregions. These results not only contribute to a better understanding of co-plasticity and co-atrophy in the hippocampus across the lifespan and in dementia, but also provide robust data-driven spatial representations (i.e. maps) for structural studies.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 27, 2020
- Source ID
- 10.1093/brain/awaa222
Entities
People
- Anna Plachti
- Christiane Jockwitz
- Deepthi P Varikuti
- Felix Hoffstaedter
- Katrin Amunts
- Sarah Genon
- Shahrzad Kharabian
- Simon B. Eickhoff
- Somayeh Maleki Balajoo
- Svenja Caspers
Organizations
- Alzheimer's Association
- Alzheimer's Disease Neuroimaging Initiative
- Alzheimer's Drug Discovery Foundation
- Biogen
- Biotechnology and Biological Sciences Research Council
- Bristol-Myers Squibb
- Canadian Institutes of Health Research
- Eli Lilly and Company
- Genentech
- German Research Foundation
- Hoffmann-La Roche
- Horizon 2020
- Istituto di Neuroscienze
- Johnson & Johnson Pharmaceutical Research and Development
- Laboratoires Servier
- Lundbeck
- Medical Research Council
- Merck & Co.
- Meso Scale Diagnostics (United States)
- National Institute of Biomedical Imaging and Bioengineering
- National Institute on Aging
- National Institutes of Health
- Northern California Institute for Research and Education
- RWTH Aachen University
- Takeda Pharmaceutical Company
- United States Department of Defense
- University of Düsseldorf
- University of Liège
- University of Southern California