Personalized brain models identify neurotransmitter receptor changes in Alzheimer's disease
Abstract
Alzheimer’s disease involves many neurobiological alterations from molecular to macroscopic spatial scales, but we currently lack integrative, mechanistic brain models characterizing how factors across different biological scales interact to cause clinical deterioration in a way that is subject-specific or personalized. As important signalling molecules and mediators of many neurobiological interactions, neurotransmitter receptors are promising candidates for identifying molecular mechanisms and drug targets in Alzheimer's disease.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 04, 2021
- Source ID
- 10.1093/brain/awab375
Entities
People
- Ahmed Faraz Khan
- Felix Carbonell
- For The Alzheimer’s Disease Neuroimaging Initiative*
- Karl Zilles
- Nicola Palomero-Gallagher
- Quadri Adewale
- Tobias R Baumeister
- Yasser Iturria-medina
Organizations
- Alzheimer's Disease Neuroimaging Initiative
- Brain Canada Foundation
- Canada First Research Excellence Fund
- Health Canada
- Istituto di Neuroscienze
- McGill University
- National Institutes of Health
- RWTH Aachen University
- United States Department of Defense
- University of Düsseldorf