Multi-ancestry GWAS reveals excitotoxicity associated with outcome after ischaemic stroke
Abstract
During the first hours after stroke onset, neurological deficits can be highly unstable: some patients rapidly improve, while others deteriorate. This early neurological instability has a major impact on long-term outcome. Here, we aimed to determine the genetic architecture of early neurological instability measured by the difference between the National Institutes of Health Stroke Scale (NIHSS) within 6 h of stroke onset and NIHSS at 24 h.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 25, 2022
- Source ID
- 10.1093/brain/awac080
Entities
People
- Agnieszka Slowik
- Alejandro Bustamante
- Alejandro Hornick
- Alessandro A Viana Oliveira Souza
- Alonso Gutierrez-romero
- Andria L Ford
- Antoni Davalos
- Antonio Arauz
- Antonio Cabezas-juan
- Boryana Stamova
- Bradley P Ander
- Carlos Cruchaga
- Carlos Molina
- Carmen Jimenez
- Carolina Soriano Tarraga
- Caty Carrera
- Chia‐Ling Phuah
- Christina Herbosa
- Cristofol Vives-bauza
- Daniel Strbian
- Elena Lopez-cancio
- Elena Muiño
- Ellen A. Tsai
- Emilio Rodriguez-castro
- Eva Giralt-steinhauer
- Fabiana H G Farias
- Francisco Campos
- Francisco Moniche
- Frank R Sharp
- Gemma Serrano-heras
- Gyeong Moon Kim
- Hajar Amini
- Iscia Lopes-cendes
- Israel Fernandez-cadenas
- Jara Cárcel-márquez
- Jaume Roquer
- Jerzy Krupinksi
- Jin Moo Lee
- Joan Martí-Fàbregas
- Joan Montaner
- Joanna Pera
- John P Budde
- Jong Won Chung
- Jordi Jimenez-conde
- Jorge L Del Aguila
- Jose Castillo-sanchez
- Joseph Bradley
- Juan Francisco Arenillas
- Justyna Derbisz
- Katarzyna Lapicka-bodzioch
- Kristy Bergmann
- Laura Heitsch
- Laura Ibanez
- Linda C Burkly
- Lucia Muñoz
- Manuel Rodríguez-yáñez
- Marc Ribo
- Marina Mola-caminal
- Miguel A Barboza
- Natalia Cullell
- Nuria P Torres-Aguila
- Oh Young Bang
- Oscar Harari
- Rajat Dhar
- Raquel Delgado-mederos
- Rebeca Marin-bueno
- Robin Lemmens
- Rodrigo Uribe-pacheco
- Rosa Diaz Navarro
- Silvia Tur
- Susana Arias-rivas
- Theodore Lowenkopf
- Tomas Segura
- Tomas Sobrino
- Turgut Tatlisumak
- Victor Obach
Organizations
- Autonomous University of Barcelona
- Biogen
- Brazilian Institute of Neuroscience and Neurotechnology
- BrightFocus Foundation
- Carlos III Health Institute
- Emergency Medicine Foundation
- Finnish Medical Foundation
- Foundation for Barnes-Jewish Hospital
- Helsinki University Central Hospital
- Hospital Universitario Central de Asturias
- Jagiellonian University
- Katholieke Universiteit Leuven
- Ministry of Science of Spain
- National Institute of Neurological Disorders and Stroke
- National Institute on Aging
- National Institutes of Health
- Providence St. Vincent Medical Center
- Sahlgrenska University Hospital
- Samsung Medical Center
- Sigrid Jusélius Foundation
- São Paulo Research Foundation
- United States Department of Defense
- University of Barcelona
- University of California, Davis
- University of Campinas
- University of Gothenburg
- University of Seville
- University of Valladolid
- University of the Balearic Islands
- Uppsala University
- Washington University in St. Louis