The effects of cytomegalovirus on brain structure following sport-related concussion
Abstract
The neurotrophic herpes virus cytomegalovirus is a known cause of neuropathology in utero and in immunocompromised populations. Cytomegalovirus is reactivated by stress and inflammation, possibly explaining the emerging evidence linking it to subtle brain changes in the context of more minor disturbances of immune function. Even mild forms of traumatic brain injury, including sport-related concussion, are major physiological stressors that produce neuroinflammation. In theory, concussion could predispose to the reactivation of cytomegalovirus and amplify the effects of physical injury on brain structure. However, to our knowledge this hypothesis remains untested.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 18, 2023
- Source ID
- 10.1093/brain/awad126
Entities
People
- Bart N Ford
- Benjamin L Brett
- Bryna D Goeckner
- Haixia Zheng
- Jaroslaw Harezlak
- Jonathan Savitz
- L. Tugan Muftuler
- Michael A. Mccrea
- Rebekah Mannix
- T. Kent Teague
- Timothy Meier
Organizations
- Boston Children's Hospital
- Harvard Medical School
- Indiana University
- Institute of Mathematical Problems of Biology
- Laureate Institute for Brain Research
- Medical College of Wisconsin
- National Center for Advancing Translational Sciences
- National Institute of General Medical Sciences
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke
- National Institutes of Health
- Oklahoma State University Center for Health Sciences
- United States Department of Defense
- University of Oklahoma
- University of Tulsa
- William K. Warren Foundation