Peripheral CCL2-CCR2 signalling contributes to chronic headache-related sensitization
Abstract
Migraine, especially chronic migraine, is highly debilitating and still lacks effective treatment. The persistent headache arises from activation and sensitization of primary afferent neurons in the trigeminovascular pathway, but the underlying mechanisms remain incompletely understood. Animal studies indicate that signalling through chemokine C-C motif ligand 2 (CCL2) and C-C motif chemokine receptor 2 (CCR2) mediates the development of chronic pain after tissue or nerve injury. Some migraine patients had elevated CCL2 levels in CSF or cranial periosteum. However, whether the CCL2-CCR2 signalling pathway contributes to chronic migraine is not clear.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 07, 2023
- Source ID
- 10.1093/brain/awad191
Entities
People
- Jintao Zhang
- Sun Ryu
- Tingting Guo
- Xuemei Liu
- Yu‐Qing Cao
- Zhaohua Guo
Organizations
- National Institutes of Health
- United States Department of Defense
- Washington University in St. Louis