Atlas55+: Brain Functional Atlas of Resting-State Networks for Late Adulthood
Abstract
Currently, several human brain functional atlases are used to define the spatial constituents of the resting-state networks (RSNs). However, the only brain atlases available are derived from samples of young adults. As brain networks are continuously reconfigured throughout life, the lack of brain atlases derived from older populations may influence RSN results in late adulthood. To address this gap, the aim of the study was to construct a reliable brain atlas derived only from older participants. We leveraged resting-state functional magnetic resonance imaging data from three cohorts of healthy older adults (total N = 563; age = 55–95 years) and a younger-adult cohort (N = 128; age = 18–35 years). We identified the major RSNs and their subdivisions across all older-adult cohorts. We demonstrated high spatial reproducibility of these RSNs with an average spatial overlap of 67%. Importantly, the RSNs derived from the older-adult cohorts were spatially different from those derived from the younger-adult cohort (P = 2.3 × 10−3). Lastly, we constructed a novel brain atlas, called Atlas55+, which includes the consensus of the major RSNs and their subdivisions across the older-adult cohorts. Thus, Atlas55+ provides a reliable age-appropriate template for RSNs in late adulthood and is publicly available. Our results confirm the need for age-appropriate functional atlases for studies investigating aging-related brain mechanisms.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 14, 2020
- Source ID
- 10.1093/cercor/bhaa321
Entities
People
- Gaelle Doucet
- Loïc Labache
- Marc Joliot
- Paul M. Thompson
- Sophia Frangou
- The Alzheimer’s Disease Neuroimaging Initiative*
Organizations
- Alternative Energies and Atomic Energy Commission
- Alzheimer's Disease Neuroimaging Initiative
- Boys Town National Research Hospital
- Icahn School of Medicine at Mount Sinai
- National Institute of Biomedical Imaging and Bioengineering
- National Institute of General Medical Sciences
- National Institute of Mental Health
- National Institute on Aging
- United States Department of Defense
- University of Bordeaux
- University of British Columbia
- University of Southern California