Altered structural covariance of locus coeruleus in individuals with significant memory concern and patients with mild cognitive impairment
Abstract
The locus coeruleus (LC) is the site where tau accumulation is preferentially observed pathologically in Alzheimer’s disease (AD) patients, but the changes in gray matter co-alteration patterns between the LC and the whole brain in the predementia phase of AD remain unclear. In this study, we estimated and compared the gray matter volume of the LC and its structural covariance (SC) with the whole brain among 161 normal healthy controls (HCs), 99 individuals with significant memory concern (SMC) and 131 patients with mild cognitive impairment (MCI). We found that SC decreased in MCI groups, which mainly involved the salience network and default mode network. These results imply that seeding from LC, the gray matter network disruption and disconnection appears early in the MCI group. The altered SC network seeding from the LC can serve as an imaging biomarker for discriminating the patients in the potential predementia phase of AD from the normal subjects.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 02, 2023
- Source ID
- 10.1093/cercor/bhad137
Entities
People
- For The Alzheimer’s Disease Neuroimaging Initiative*
- Jun Shen
- Meiwei Chen
- Minghui Cao
- Xiaoyan Wu
- Yingmei Tang
- Yunhua Li
- Yuting Lin
Organizations
- National Institute of Biomedical Imaging and Bioengineering
- National Institute on Aging
- National Institutes of Health
- South China Normal University
- Sun Yat-sen University
- United States Department of Defense