Preferential Infection of α4β7+ Memory CD4+ T Cells During Early Acute Human Immunodeficiency Virus Type 1 Infection
Abstract
Establishment of persistent human immunodeficiency virus type 1 (HIV-1) reservoirs occurs early in infection, and biomarkers of infected CD4+ T cells during acute infection are poorly defined. CD4+ T cells expressing the gut homing integrin complex α4β7 are associated with HIV-1 acquisition, and are rapidly depleted from the periphery and gastrointestinal mucosa during acute HIV-1 infection.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 29, 2020
- Source ID
- 10.1093/cid/ciaa497
Entities
People
- Aida Sivro
- Alexandra Schuetz
- Amélie Pagliuzza
- Andrey Tokarev
- Diane L Bolton
- Eugène Kroon
- Jintanat Ananworanich
- Lyle R. Mckinnon
- Merlin L Robb
- Michael A Eller
- Nicolas Chomont
- Nitiya Chomchey
- Nittaya Phanuphak
- Tosin E Omole
Organizations
- Armed Forces Research Institute of Medical Sciences
- CAPRISA
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- Merck & Co.
- Thai Red Cross Society
- United States Department of Defense
- University of Manitoba
- Université de Montréal
- ViiV Healthcare
- Walter Reed Army Institute of Research