Phage Therapy for Limb-threatening Prosthetic KneeKlebsiella pneumoniaeInfection: Case Report and In Vitro Characterization of Anti-biofilm Activity
Abstract
Prosthetic joint infection (PJI) is a potentially limb-threatening complication of total knee arthroplasty. Phage therapy is a promising strategy to manage such infections including those involving antibiotic-resistant microbes, and to target microbial biofilms. Experience with phage therapy for infections associated with retained hardware is limited. A 62-year-old diabetic man with a history of right total knee arthroplasty 11 years prior who had suffered multiple episodes of prosthetic knee infection despite numerous surgeries and prolonged courses of antibiotics, with progressive clinical worsening and development of severe allergies to antibiotics, had been offered limb amputation for persistent right prosthetic knee infection due to Klebsiella pneumoniae complex. Intravenous phage therapy was initiated as a limb-salvaging intervention.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 23, 2020
- Source ID
- 10.1093/cid/ciaa705
Entities
People
- Biswajit Biswas
- Bri’anna Horne
- David G Lewallen
- Edison J Cano
- Francisco Malagon
- Gina A Suh
- Jonas D Van Belleghem
- Joseph Fackler
- Katherine M Caflisch
- Matthew Henry
- Michael J. Brownstein
- Paul L Bollyky
- Robin Patel
Organizations
- Geneva Foundation
- Mayo Clinic
- National Center for Advancing Translational Sciences
- National Institutes of Health
- Naval Medical Research Center
- Stanford University