Delineating the molecular and histological events that govern right ventricular recovery using a novel mouse model of pulmonary artery de-banding

Abstract

The temporal sequence of events underlying functional right ventricular (RV) recovery after improvement of pulmonary hypertension-associated pressure overload is unknown. We sought to establish a novel mouse model of gradual RV recovery from pressure overload and use it to delineate RV reverse-remodelling events.

Document Details

Document Type
Pub Defense Publication
Publication Date
Nov 18, 2019
Source ID
10.1093/cvr/cvz310

Entities

People

  • Edda Spiekerkoetter
  • Kazuya Kuramoto
  • Kenzo Ichimura
  • Khadem Ali
  • Mario Boehm
  • Melanie J. Dufva
  • Ross J Metzger
  • Sushma Reddy
  • Svenja Dannewitz Prosseda
  • Vitaly O Kheyfets
  • Xuefei Tian
  • Yiwei Shi
  • Yuqiang Mao

Organizations

  • Children's Hospital Colorado
  • China Medical University
  • Istituto Superiore di Sanità
  • Max Kade Foundation
  • National Heart, Lung, and Blood Institute
  • National Institutes of Health
  • Pulmonary Hypertension Association
  • Stanford University
  • United States Department of Defense
  • University of Colorado Denver

Tags

Fields of Study

  • Biology

Readers

  • Naval Architecture and Marine Engineering.
  • Theoretical Analysis.
  • Trauma Surgery or Emergency Medicine.