Overexpression of Vitamin D Receptor in Intestinal Epithelia Protects Against Colitis via Upregulating Tight Junction Protein Claudin 15
Abstract
Dysfunction of the vitamin D receptor [VDR] contributes to the aetiology of IBD by regulating autophagy, immune response, and mucosal permeability. VDR directly controls the paracellular tight junction protein Claudin-2. Claudin-2 and Claudin-15 are unique in maintaining paracellular permeability. Interestingly, claudin-15 mRNA was downregulated in patients with ulcerative colitis. However, the exact mechanism of Claudin-15 regulation in colitis is still unknown. Here, we investigated the protective role of VDR against intestinal inflammation via upregulating Claudin-15.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 05, 2021
- Source ID
- 10.1093/ecco-jcc/jjab044
Entities
People
- Ishita Chatterjee
- Jilei Zhang
- Jun Sun
- Rong Lu
- Yinglin Xia
- Yongguo Zhang
Organizations
- Jesse Brown VA Medical Center
- National Institute of Diabetes and Digestive and Kidney Diseases
- United States Department of Defense
- University of Illinois at Chicago