Extracellular vesicles from immortalized cardiosphere-derived cells attenuate arrhythmogenic cardiomyopathy in desmoglein-2 mutant mice
Abstract
Arrhythmogenic cardiomyopathy (ACM) is characterized by progressive loss of cardiomyocytes, and fibrofatty tissue replacement. Extracellular vesicles (EVs) secreted by cardiosphere-derived cells, immortalized, and engineered to express high levels of β-catenin, exert anti-inflammatory, and anti-fibrotic effects. The aim of the current study was to assess efficacy of EVs in an ACM murine model.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 29, 2021
- Source ID
- 10.1093/eurheartj/ehab419
Entities
People
- Ahmed Gamal-Eldin Ibrahim
- Chang Li
- Di Wu
- Eduardo Marban
- Eugenio Cingolani
- Lizbeth Sanchez
- Rui Zhang
- Russell George Rogers
- Thássio Ricardo Ribeiro Mesquita
- Weixin Liu
- Xinling Li
- Yen‐Nien Lin
- Yin-huei Chen
- Yizhou Wang
Organizations
- Cedars-Sinai Medical Center
- China Medical University Hospital
- National Institutes of Health
- United States Department of Defense