A Mixed-Effects Model of Associations Between Interleukin-6 and Hippocampal Volume
Abstract
Previous studies report hippocampal volume loss can help predict conversion from normative aging to mild cognitive impairment to dementia. Additionally, a growing literature indicates that stress-related allostatic load may increase disease vulnerability. The current study examined the relationship between stress-related cytokines (ie, interleukin-6 [IL-6]), cognition as measured by Mini-Mental State Examination (MMSE) scores, and hippocampal volume. Mixed models were employed to examine both within- (across time) and between-subject effects of IL-6 and hippocampal volume on MMSE score among 566 participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). The within-subject analysis found left hippocampal volume significantly (p = .009) predicted MMSE score. Between-subject analysis found the effect of IL-6 on MMSE was moderated by right hippocampal volume (p = .001). These results replicate previous findings and also extend prior work demonstrating stress-related cytokines may play a role in Alzheimer’s disease progression.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 12, 2021
- Source ID
- 10.1093/gerona/glab313
Entities
People
- Chuong Bui
- Erin R. Harrell
- Sharlene D Newman
- The Alzheimer's Disease Neuroimaging Initiative (adni)
Organizations
- Alzheimer's Disease Neuroimaging Initiative
- National Institutes of Health
- United States Department of Defense
- University of Alabama