Senescence and Inflammation: Summary of a Gerontological Society of America and National Institute on Aging-Sponsored Symposium
Abstract
The National Institute on Aging sponsored a symposium at the Gerontological Society of America (GSA) annual meeting in Indianapolis, Indiana, to discuss recent discoveries related to senescent and inflammatory mechanisms in aging and disease. Consistent with the 2022 Biological Sciences GSA program led by Dr. Rozalyn Anderson, the symposium featured early-stage investigators and a leader in the field of geroscience research. Cell senescence and immune interactions coordinate homeostatic and protective programming throughout the life span. Dysfunctional communication in this exchange eventuates in inflammation-related compositional changes in aged tissues, including propagation of the senescence-associated secretory phenotype and accumulation of senescent and exhausted immune cells. Presentations in this symposium explored senescent and immune-related dysfunction in aging from diverse viewpoints and featured emerging cellular and molecular methods. A central takeaway from the event was that the use of new models and approaches, including single-cell -omics, novel mouse models, and 3D culture systems, is revealing dynamic properties and interactions of senescent and immune cell fates. This knowledge is critical for devising new therapeutic approaches with important translational relevance.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 06, 2023
- Source ID
- 10.1093/gerona/glad120
Entities
People
- Birgit Schilling
- Daniel J Tyrrell
- Marissa J Schafer
- Matthew J. Yousefzadeh
- Tamara Alliston
- Xu Zhang
Organizations
- Buck Institute for Research on Aging
- Glenn Foundation for Medical Research
- Mayo Clinic
- National Institute on Aging
- National Institutes of Health
- United States Department of Defense
- University of Alabama at Birmingham
- University of California, San Francisco
- University of Minnesota