Serum IgG4 Subclass Deficiency Defines a Distinct, Commonly Encountered, Severe Inflammatory Bowel Disease Subtype
Abstract
Immunoglobulin G subclass 4 (IgG4) is hypothesized to play an immunomodulatory role, downregulating humoral immune responses. The role of this anti-inflammatory molecule in inflammatory bowel disease (IBD) has not been fully characterized. We sought to define alterations in serum IgG4 in patients with IBD and their association with multiyear disease severity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 03, 2020
- Source ID
- 10.1093/ibd/izaa230
Entities
People
- Anna Evans Phillips
- Arthur Barrie
- Claudia Ramos Rivers
- David G. Binion
- Dhiraj Yadav
- Dmitriy Babichenko
- Douglas J Hartman
- Elyse Johnston
- Filippos Koutroumpakis
- Gong Tang
- Hasieb Din
- Jana G. Hashash
- Janet Harrison
- Jeffrey Dueker
- Jorge D Machicado
- Liza Konnikova
- Maaz Ahsan
- Marc Schwartz
- Michael A. Dunn
- Siobhan Proksell
- Xiaoqing Tan
Organizations
- United States Department of Defense
- University of Pittsburgh
- University of Pittsburgh Medical Center
- University of Pittsburgh School of Medicine