Adipokine Resistin Levels at Time of Pediatric Crohn Disease Diagnosis Predict Escalation to Biologic Therapy
Abstract
Hypertrophy of visceral adipose tissue (VAT) is a hallmark of Crohn disease (CD). The VAT produces a wide range of adipokines, biologically active factors that contribute to metabolic disorders in addition to CD pathogenesis. The study aim was to concomitantly evaluate serum adipokine profiles and VAT volumes as predictors of disease outcomes and treatment course in newly diagnosed pediatric patients with CD.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 26, 2020
- Source ID
- 10.1093/ibd/izaa250
Entities
People
- Claudio Fiocchi
- Erick M Remer
- Iulia Barbur
- Jacob A Kurowski
- Jean-paul Achkar
- Marsha H Kay
- Rishi Gupta
- Sarah Worley
- Satish E Viswanath
- Tracey L Bonfield
Organizations
- Case Western Reserve University
- Cleveland Clinic
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institutes of Health
- University of Rochester