Role of Lymphatic Deficiency in the Pathogenesis and Progression of Inflammatory Bowel Disease to Colorectal Cancer in an Experimental Mouse Model
Abstract
Inflammatory bowel disease (IBD) is characterized by chronic inflammation, which can progress to colorectal cancer, with duration of disease being the most important risk factor. Although many factors are involved, the pathogenic link between inflammation and cancer and the role played by the lymphatic system have not been fully investigated. This project uses lymphatic-deficient mice (Angiopoietin-2 [Ang2] knockout) to examine the lymphatic system in the progression of IBD to colorectal cancer.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 07, 2019
- Source ID
- 10.1093/ibd/izz112
Entities
People
- J. Steven Alexander
- Jalicia Washington
- Jennifer Thorn
- Marlys H. Witte
- Michael Bernas
- Nathan Tanoue
- Pawel Kiela
- Sarah K Daley
Organizations
- National Institutes of Health
- Texas Christian University
- United States Department of Defense
- University of Arizona