Association between genetically predicted polycystic ovary syndrome and ovarian cancer: a Mendelian randomization study
Abstract
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder with an estimated prevalence of 4–21% in reproductive aged women. Recently, the Ovarian Cancer Association Consortium (OCAC) reported a decreased risk of invasive ovarian cancer among women with self-reported PCOS. However, given the limitations of self-reported PCOS, the validity of these observed associations remains uncertain. Therefore, we sought to use Mendelian randomization with genetic markers as a proxy for PCOS, to examine the association between PCOS and ovarian cancer.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 01, 2019
- Source ID
- 10.1093/ije/dyz113
Entities
People
- Allan Jensen
- Andrew Berchuck
- Anna H. Wu
- Argyrios Ziogas
- Celeste L. Pearce
- Christina M Nagle
- Daniel W. Cramer
- Elisa V. Bandera
- Estrid Høgdall
- Francesmary Modugno
- Harvey A. Risch
- Hoda Anton-Culver
- Holly R Harris
- Jennifer A Doherty
- Joanne Kotsopoulos
- Joellen M. Schildkraut
- John R. Mclaughlin
- Kara L. Cushing-haugen
- Kathryn L. Terry
- Kirsten B. Moysich
- Lorna Rodriguez
- Marc T. Goodman
- Mary Anne Rossing
- Nicolas Wentzensen
- Penelope M. Webb
- Roberta B. Ness
- Sara Lindström
- Steven A. Narod
- Susan J. Jordan
- Susanne K. Kjær
- The Australian Ovarian Cancer Study Group
- The Ovarian Cancer Association Consortium
Organizations
- California Breast Cancer Research Program
- Cancer Council Australia
- Cedars-Sinai Medical Center
- Danish Cancer Society
- Duke University
- Fred Hutchinson Cancer Center
- Harvard Medical School
- Harvard University
- National Cancer Institute
- National Health and Medical Research Council
- National Institutes of Health
- Ovarian Cancer Research Alliance
- Public Health Ontario
- QIMR Berghofer Medical Research Institute
- Robert Wood Johnson Medical School
- Roswell Park Comprehensive Cancer Center
- United States Department of Defense
- University of California, Irvine
- University of Copenhagen
- University of Michigan
- University of Pittsburgh School of Medicine
- University of Queensland
- University of Southern California
- University of Texas at Austin
- University of Toronto
- University of Utah
- University of Virginia
- University of Washington
- Yale School of Public Health