Epigenetic Regulation of GABAergic Neurotransmission and Neurosteroid Biosynthesis in Alcohol Use Disorder
Abstract
Alcohol use disorder (AUD) is a chronic relapsing brain disorder. GABAA receptor (GABAAR) subunits are a target for the pharmacological effects of alcohol. Neurosteroids play an important role in the fine-tuning of GABAAR function in the brain. Recently, we have shown that AUD is associated with changes in DNA methylation mechanisms. However, the role of DNA methylation in the regulation of neurosteroid biosynthesis and GABAergic neurotransmission in AUD patients remains under-investigated.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 24, 2020
- Source ID
- 10.1093/ijnp/pyaa073
Entities
People
- Alessandro Guidotti
- Dario Aspesi
- Dennis R Grayson
- Eleonora Gatta
- Graziano Pinna
- Subhash C Pandey
- Vikram Saudagar
Organizations
- National Institute on Alcohol Abuse and Alcoholism
- United States Department of Defense
- University of Illinois at Chicago