Characterization of 2 Novel Phosphodiesterase 2 Inhibitors Hcyb1 and PF-05180999 on Depression- and Anxiety-Like Behavior
Abstract
Phosphodiesterase 2A (PDE2A) represents a novel target for new therapies addressing psychiatric disorders. To date, the development of PDE2A inhibitors suitable for human clinical evaluation has been hampered by the poor brain accessibility and metabolic stability of the available compounds.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 19, 2023
- Source ID
- 10.1093/ijnp/pyad020
Entities
People
- Abhinav P. Acharya
- Chang-Guo Zhan
- Fu Du
- Jianghong Ye
- Wei Wang
- Xiongwei Zhu
- Ying Xu
- Yue M. Lu
- Yuhan Zhao
- Yuqing Yan
Organizations
- Arizona State University
- Case Western Reserve University
- National Institute on Aging
- Rutgers University
- University of Arizona
- University of Kentucky