A Phase IIa Controlled Human Malaria Infection and Immunogenicity Study of RTS,S/AS01E and RTS,S/AS01B Delayed Fractional Dose Regimens in Malaria-Naive Adults
Abstract
A previous RTS,S/AS01B vaccine challenge trial demonstrated that a 3-dose (0-1-7–month) regimen with a fractional third dose can produce high vaccine efficacy (VE) in adults challenged 3 weeks after vaccination. This study explored the VE of different delayed fractional dose regimens of adult and pediatric RTS,S/AS01 formulations.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 20, 2020
- Source ID
- 10.1093/infdis/jiaa421
Entities
People
- April K Sikaffy
- Aurélia Leprince
- Christian Ockenhouse
- Christine E Lee
- Cynthia Lee
- Danielle Morelle
- Donna M Tosh
- Elizabeth H. Duncan
- Elke S Bergmann-Leitner
- Erik Jongert
- Evelina Angov
- Ilin Chuang
- Jack L. Komisar
- Jack N Hutter
- James Moon
- Jason A. Regules
- Jason W. Bennett
- Jennifer Kooken
- Jessica J Cowden
- Johan Vekemans
- Judith E. Epstein
- Justin M Curley
- Karen Ivinson
- Kristin T. Mills
- Kyle Peterson
- Linda Murray
- Lindsey S Garver
- Magali Traskine
- Marc Lievens
- Mark S. Riddle
- Martha Sedegah
- Melinda J Hamer
- Michael A. Koren
- Michele D Spring
- Nathanial K Copeland
- Norman C. Waters
- Opokua Ofori-anyinam
- Paige E. Waterman
- Rts,s Malaria Vaccine Working Group
- Susan B Cicatelli
- Viseth Ngauy
- William Ripley Ballou
Organizations
- Naval Medical Research Center
- United States Department of Defense
- Walter Reed Army Institute of Research