Epitope-Specific Antibody Responses to a Plasmodium falciparum Subunit Vaccine Target in a Malaria-Endemic Population
Abstract
Circumsporozoite protein (CSP) coats the Plasmodium falciparum sporozoite surface and is a major malaria subunit vaccine target. We measured epitope-specific reactivity to field-derived CSP haplotypes in serum samples from Malian adults and children on a custom peptide microarray. Compared to children, adults showed greater antibody responses and responses to more variants in regions proximal to and within the central repeat region. Children acquired short-lived immunity to an epitope proximal to the central repeat region but not to the central repeat region itself. This approach has the potential to differentiate immunodominant from protective epitope-specific responses when combined with longitudinal infection data.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 29, 2020
- Source ID
- 10.1093/infdis/jiaa611
Entities
People
- Abdoulaye K. Kone
- Amed Ouattara
- Andrea A Berry
- Andrew Pike
- Bourèma Kouriba
- Christopher V. Plowe
- Deanna Friedman-Klabanoff
- Drissa Coulibaly
- Jason A Bailey
- Jigar J Patel
- John C. Tan
- Kirsten E. Lyke
- Mahamadou A. Thera
- Mark A Travassos
- Matthew Adams
- Matthew B. Laurens
- Ogobara K. Doumbo
- Olukemi O Ifeonu
- Philip L. Felgner
- Shannon Takala-harrison
- Sonia Agrawal
Organizations
- American Society of Tropical Medicine and Hygiene
- Burroughs Wellcome Fund
- Centre Pour le Développement des Vaccins-Mali
- John E. Fogarty International Center
- National Heart, Lung, and Blood Institute
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- United States Agency for International Development
- United States Department of Defense
- University of California