Distribution and Temporal Dynamics of Plasmodium falciparum Chloroquine Resistance Transporter Mutations Associated With Piperaquine Resistance in Northern Cambodia
Abstract
Newly emerged mutations within the Plasmodium falciparum chloroquine resistance transporter (PfCRT) can confer piperaquine resistance in the absence of amplified plasmepsin II (pfpm2). In this study, we estimated the prevalence of co-circulating piperaquine resistance mutations in P. falciparum isolates collected in northern Cambodia from 2009 to 2017.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 02, 2021
- Source ID
- 10.1093/infdis/jiab055
Entities
People
- Andrew P Morgan
- Biraj Shrestha
- Brian A Vesely
- Chaiyaporn Chaisatit
- Chanthap Lon
- Chantida Praditpol
- Charlotte A. Lanteri
- Darapiseth Sea
- David L. Saunders
- Dysoley Lek
- Huy Rekol
- Jessica T Lin
- Mariusz Wojnarski
- Matthew Adams
- Michele D Spring
- Molly Deutsch-Feldman
- Nonlawat Boonyalai
- Norman C. Waters
- Panita Gosi
- Paphavee Lertsethtakarn
- Philip L. Smith
- Piyaporn Saingam
- Prom Satharath
- Shannon Takala-harrison
- Soklyda Chann
- Somethy Sok
- Stuart D. Tyner
- Suwanna Chaorattanakawee
- Zalak Shah
Organizations
- Armed Forces Research Institute of Medical Sciences
- Mahidol University
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- National Malaria Center of Cambodia
- Royal Cambodian Armed Forces
- United States Army Medical Research Institute of Infectious Diseases
- United States Department of Defense
- University of North Carolina at Chapel Hill