Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit
Abstract
The NIH Virtual SARS-CoV-2 Antiviral Summit, held on 6 November 2020, was organized to provide an overview on the status and challenges in developing antiviral therapeutics for coronavirus disease 2019 (COVID-19), including combinations of antivirals. Scientific experts from the public and private sectors convened virtually during a live videocast to discuss severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targets for drug discovery as well as the preclinical tools needed to develop and evaluate effective small-molecule antivirals. The goals of the Summit were to review the current state of the science, identify unmet research needs, share insights and lessons learned from treating other infectious diseases, identify opportunities for public-private partnerships, and assist the research community in designing and developing antiviral therapeutics. This report includes an overview of therapeutic approaches, individual panel summaries, and a summary of the discussions and perspectives on the challenges ahead for antiviral development.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 10, 2021
- Source ID
- 10.1093/infdis/jiab305
Entities
People
- Abigail C Grossman
- Andrew D Mesecar
- Annaliesa Anderson
- Anthony J Conley
- Anthony S. Fauci
- Celia A. Schiffer
- Charlotte A. Lanteri
- Christopher P Austin
- Courtney V Fletcher
- Daria J Hazuda
- David Baker
- Elizabeth A Campbell
- Emmie de Wit
- Francis S. Collins
- Frederick G Hayden
- George Painter
- Hilary Marston
- Hugh D Smyth
- James M. Anderson
- Jay Bradner
- Jennifer O Nwankwo
- Jules O’rear
- Kara Carter
- Kizzmekia S. Corbett
- Kumar Singh Saikatendu
- Kyle R Brimacombe
- Lillian Chiang
- Mark R. Denison
- Marla Weetall
- Matthew D Disney
- Matthew D. Hall
- Matthias Götte
- Michael J Sofia
- Mindy I. Davis
- Pei-Yong Shi
- Richard Whitley
- Sandra K Weller
- Sara Cherry
- Stephanie L Ford-scheimer
- Stephanie Moore
- Timothy P. Sheahan
- Tomas Cihlar
Organizations
- Emory University
- Evotec
- Evrys Bio
- Food and Drug Administration
- Gilead Sciences
- Merck & Co.
- National Center for Advancing Translational Sciences
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- Novartis Institutes for BioMedical Research
- Office of the Director
- PTC Therapeutics
- Pfizer
- Purdue University
- Scripps Research
- The Rockefeller University
- University of Alabama at Birmingham
- University of Alberta
- University of Connecticut School of Medicine
- University of Massachusetts Medical School
- University of Nebraska–Lincoln
- University of North Carolina
- University of Pennsylvania
- University of Texas Medical Branch
- University of Texas at Austin
- University of Virginia
- University of Washington
- Vanderbilt University
- Walter Reed Army Institute of Research