M2-Deficient Single-Replication Influenza Vaccine–Induced Immune Responses Associated With Protection Against Human Challenge With Highly Drifted H3N2 Influenza Strain

Abstract

Current influenza vaccines are strain specific and demonstrate low vaccine efficacy against H3N2 influenza disease, especially when vaccine is mismatched to circulating virus. The novel influenza vaccine candidate, M2-deficient single replication (M2SR), induces a broad, multi-effector immune response.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jul 29, 2021
Source ID
10.1093/infdis/jiab374

Entities

People

  • Bram Volckaert
  • David Marshall
  • Gabriele Neumann
  • Harry B. Greenberg
  • Joseph Eiden
  • Kathleen Coelingh
  • Oleg Rudenko
  • Pamuk Bilsel
  • Renee Herber
  • Robert Belshe
  • Roger Aitchison
  • Yoshihiro Kawaoka

Organizations

  • FluGen
  • Saint Louis University
  • Stanford University
  • University of Wisconsin–Madison

Tags

Fields of Study

  • Biology

Readers

  • Immunology
  • Infectious Disease/Epidemiology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech