Hyperimmune Bovine Colostral Anti-CS17 Antibodies Protect Against Enterotoxigenic Escherichia coli Diarrhea in a Randomized, Doubled-Blind, Placebo-Controlled Human Infection Model
Abstract
Enterotoxigenic Escherichia coli (ETEC) commonly cause diarrhea in children living in developing countries and in travelers to those regions. ETEC are characterized by colonization factors (CFs) that mediate intestinal adherence. We assessed if bovine colostral IgG (bIgG) antibodies against a CF, CS17, or antibodies against CsbD, the minor tip subunit of CS17, would protect subjects against diarrhea following challenge with a CS17-expressing ETEC strain.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 21, 2019
- Source ID
- 10.1093/infdis/jiz135
Entities
People
- A. Louis Bourgeois
- Aisling O’dowd
- Barbara Denearing
- Carl Brinkley
- Chad K Porter
- Colleen M. Woods
- David R. Tribble
- Hye Kim
- Joseph H Crabb
- Robin Mckenzie
- Shannon L. Grahek
- Stephanie A. Sincock
- Stephen J. Savarino
- Steven T Poole
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- Johns Hopkins Bloomberg School of Public Health
- Johns Hopkins School of Medicine
- Naval Medical Research Center
- United States Army Medical Research and Development Command
- Walter Reed Army Institute of Research