Serological Evidence for Henipa-like and Filo-like Viruses in Trinidad Bats
Abstract
Bat-borne zoonotic pathogens belonging to the family Paramxyoviridae, including Nipah and Hendra viruses, and the family Filoviridae, including Ebola and Marburg viruses, can cause severe disease and high mortality rates on spillover into human populations. Surveillance efforts for henipaviruses and filoviruses have been largely restricted to the Old World; however, recent studies suggest a potentially broader distribution for henipaviruses and filoviruses than previously recognized. In the current study, we screened for henipaviruses and filoviruses in New World bats collected across 4 locations in Trinidad near the coast of Venezuela. Bat tissue samples were screened using previously established reverse-transcription polymerase chain reaction assays. Serum were screened using a multiplex immunoassay to detect antibodies reactive with the envelope glycoprotein of viruses in the genus Henipavirus and the family Filoviridae. Serum samples were also screened by means of enzyme-linked immunosorbent assay for antibodies reactive with Nipah G and F glycoproteins. Of 84 serum samples, 28 were reactive with ≥1 henipavirus glycoprotein by ≥1 serological method, and 6 serum samples were reactive against ≥1 filovirus glycoproteins. These data provide evidence of potential circulation of viruses related to the henipaviruses and filoviruses in New World bats.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 08, 2020
- Source ID
- 10.1093/infdis/jiz648
Entities
People
- Alexandre Tremeau-bravard
- Christine V F Carrington
- Christopher C Broder
- Eric D. Laing
- Janine F R Seetahal
- Jerome Foster
- John T Thompson
- Jonathan E Schulz
- Jonathan H. Epstein
- Lianying Yan
- M Jeremiah Matson
- Michael C Letko
- Robert J. Fischer
- Simon J. Anthony
- Spencer L. Sterling
- Stephanie N Seifert
- Tony Schountz
- Tracey Goldstein
- Vernie Ramkissoon
- Victoria Avanzato
- Vincent J. Munster
Organizations
- Colorado State University
- Columbia University
- Defense Threat Reduction Agency
- EcoHealth Alliance
- Marshall University
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- Uniformed Services University of the Health Sciences
- University of California
- University of the West Indies