SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a Subset of TTF-1–Negative Lung Adenocarcinomas
Abstract
Approximately 20% of lung adenocarcinoma (LUAD) is negative for the lineage-specific oncogene Thyroid transcription factor 1 (TTF-1) and exhibits worse clinical outcome with a low frequency of actionable genomic alterations. To identify molecular features associated with TTF-1–negative LUAD, we compared the transcriptomic and proteomic profiles of LUAD cell lines. SRGN , a chondroitin sulfate proteoglycan Serglycin, was identified as a markedly overexpressed gene in TTF-1–negative LUAD. We therefore investigated the roles and regulation of SRGN in TTF-1–negative LUAD.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 15, 2021
- Source ID
- 10.1093/jnci/djab183
Entities
People
- Adi F. Gazdar
- Ayumu Taguchi
- Barbara Mino
- Carmen Behrens
- Clemente Aguilar-Bonavides
- Delphine Daydé
- Dilsher Dhillon
- Edwin Justin Ostrin
- Edwin Roger Parra
- Francesco C. Stingo
- Gargy Parhy
- Haruki Mori
- Hiroyuki Katayama
- Hong Wang
- Ichidai Tanaka
- Ignacio I. Wistuba
- Jaime Rodriguez-canales
- Jennifer B. Dennison
- Johannes F. Fahrmann
- Julian Phillip Casabar
- Junya Fujimoto
- Kim-anh Do
- Kohei Yokoi
- Koji Kawaguchi
- Luisa M Solis
- Masahiro Nakatochi
- Mei Chee Tai
- Müge Çeliktaş
- Neşe Ünver
- Philip L Lorenzi
- Rekha Jain
- Samir M Hanash
- Satyendra C. Tripathi
- Seiichi Kato
- Taisuke Kajino
- Takayuki Fukui
- Tetsunari Hase
- Toyofumi F Chen-yoshikawa
- Veera Baladandayuthapani
- Waki Hosoda
- Yasushi Yatabe
- Yoshiko Murakami
- Yoshinori Hasegawa
Organizations
- Aichi Cancer Center Hospital
- Canary Foundation
- Cancer Prevention and Research Institute of Texas
- Daiko Foundation
- Japan Society for the Promotion of Science
- LUNGevity Foundation
- Nagoya University
- National Cancer Institute
- United States Department of Defense
- University of Florence
- University of Texas at Austin
- Zhejiang University