HER2-Enriched Subtype and ERBB2 Expression in HER2-Positive Breast Cancer Treated with Dual HER2 Blockade

Abstract

Identification of HER2-positive breast cancers with high anti-HER2 sensitivity could help de-escalate chemotherapy. Here, we tested a clinically applicable RNA-based assay that combines ERBB2 and the HER2-enriched (HER2-E) intrinsic subtype in HER2-positive disease treated with dual HER2-blockade without chemotherapy.

Document Details

Document Type
Pub Defense Publication
Publication Date
Apr 30, 2019
Source ID
10.1093/jnci/djz042

Entities

People

  • Aleix Prat
  • Andres Forero
  • Anne C Pavlick
  • Antonio C. Wolff
  • Antonio Llombart-cussac
  • Barbara Adamo
  • Begoña Bermejo
  • Brent Rexer
  • C. Kent Osborne
  • Carmine De Angelis
  • Carolina Gutierrez
  • Fara Brasó-maristany
  • Gaia Griguolo
  • Ian Krop
  • Jamunarani Veeraraghavan
  • Javier Cortés
  • Joel S Parker
  • Jorge S Reis-Filho
  • Laia Paré
  • Mafalda Oliveira
  • Maria Vidal
  • Maria Vittoria Dieci
  • Miguel Izquierdo
  • Mothaffar F Rimawi
  • Paolo Nuciforo
  • Patricia Galván
  • Pierfranco Conte
  • Rachel Schiff
  • Roberta Fasani
  • Serafín Morales
  • Susan Hilsenbeck
  • Tao Wang
  • Tomás Pascual
  • Valentina Guarneri
  • Vanessa Rodrik-outmezguine

Organizations

  • Banco Bilbao Vizcaya Argentaria
  • Baylor College of Medicine
  • Carlos III Health Institute
  • Dana–Farber Cancer Institute
  • GSK
  • Hospital Clinic of Barcelona
  • Istituto Oncologico Veneto
  • Johns Hopkins University
  • Memorial Sloan Kettering Cancer Center
  • National Institutes of Health
  • Novartis
  • Spanish Association Against Cancer
  • The Breast Cancer Research Foundation
  • United States Department of Defense
  • University of Alabama at Birmingham
  • University of North Carolina
  • University of Padua
  • Vall d'Hebron Hospital Universitari
  • Vanderbilt University

Tags

Readers

  • Breast cancer cell signaling and growth regulation.
  • Oncology